FUNCTIONAL MRI (fMRI)

The use of functional MRI (fMRI) in neurophysiological pain research and, in a lesser extent, in clinical practice, is an ever-growing field. Research efforts in this field have uncovered the mechanism of brain response to different types of stimuli in health and disease. Imaging pain requires thermal stimulators that can safely and accurately deliver noxious and non-noxious stimuli within a neuroimaging environment for extended periods of time.

Background

The plasticity of the human brain grants momentary or lasting functional changes in response to internal and external processes, like disease or exposure to pain.  In some chronic pain conditions such as fibromyalgia syndrome and chronic low back pain, responses to experimental pain are reflected in abnormal BOLD responses in specific brain regions that are involved in pain processing.

Therefore, imaging brain activity in health and in chronic pain conditions can contribute to understanding the mechanism of chronic pain development, learning which factors affect pain perception, how painful stimuli can affect one's behavior, and more.

Our solution

 

Medoc’s TSA 2 can be suited with fMRI-compatible thermodes to administer thermal painful and non-painful stimuli within the scanner. Also, the TSA 2 can also include fMRI-compatible CHEPS thermodes, capable of delivering very rapid heat or cold stimuli. Our TSA 2 system has TTL-in and -out capabilities for precise synchronization with MRI scanner. The stimuli can also be controlled using third-party software such as MATLAB™ and E-Prime™, providing flexible and advanced control over the experimental parameters and allowing synchronization with additional stimuli and measures.

TSA 2 can be equipped with two thermodes which allow synchronized stimulation of multiple body sites at the same time, from one device and software interface. This can serve for advanced protocols like conditioned pain modulation (CPM) or spatial summation.

Medoc's fMRI systems are used by researchers at the Harvard University Medical School, University of Duisburg-Essen, the University of Toronto, the University of Munich, the University of Birmingham in Alabama, University of Colorado Boulder, the Veterans General Hospital, and National Yang-Ming University in Taipei, and in over 150 other locations worldwide.

 

Using the TSA-2 in the fMRI environment

 

Our TSA 2 system is suitable for use in an fMRI setting with its MRI conditional accessories. The device is situated outside of the Faraday cage while thermodes and response accessories are inserted into the scanner environment via the penetration panel.

 

Our fMRI-compatible solutions include:

 

fMRI-conditional thermodes 30x30mm / 16x16mm / 24x24 mm CHEPS thermode

Dual thermode set-up for simultaneous stimulation by two thermodes through one TSA 2 device

13m cable

TTL Output for triggering external device

TTL Input for triggering the TSA 2 from third-party device

Standard external control capabilities

Medoc Ltd.

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